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KMID : 1202020090020020114
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Journal of Korean Thyroid Association
2009 Volume.2 No. 2 p.114 ~ p.119
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Serum Ghrelin Levels in Hypothyroidism Patients
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Kim Hyun-Sook
Sohn Ho-Sang
Jung Eui-Dal
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Abstract
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Background and Objectives : Ghrelin stimulates growth hormone secretion and food intake. Ghrelin regulates energy expenditure. Thyroid dysfunction is associated with weight changes and metabolism. However, findings between serum ghrelin level and hypothyroidism are conflicting.
Materials and Methods :We studied 20 overt hypothyroidism patients, 16 subclinical hypothyroidism patients, and 45 euthyroid controls. Thyroid hormones, thyroid autoantibodies, fasting glucose, acylated ghrelin, insulin, and urine iodide were measured in all subjects.
Results: Baseline characteristics (age, sex, BMI, waist circumference) between hypothyroidism (subclinical and overt hypothyroid) patients and controls were similar. Serum acylated ghrelin levels in hypothyroidism patients did not differ from those in controls (15.7±18.9 pg/ml vs 20.2±37.2 pg/ml, p=0.714). Serum insulin levels in hypothyroidism patients did not differ from those in controls. serum acylated ghrelin levels and insulin levels of overt hypothyrodism were not different compared with euthyroid controls (acylated ghrelin; 16.8±20.8 pg/ml vs 20.2±37.2 pg/ml, p=0.43).
Conclusion:Serum acylated ghrelin levels in hypothyroidism patients did not differ from those in controls. Further evaluations are needed to clarify relationship between ghrelin levels and thyroid dysfunction.
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KEYWORD
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Ghrelin, Hypothyroidism, Insulin
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